Yes, bone loss is a known side effect of anastrozole and other aromatase inhibitors. Because these medications lower estrogen levels, they can reduce bone density over time — first leading to osteopenia (early bone thinning), and potentially progressing to osteoporosis (brittle bones).
Research also suggests that Show Full Answer
Yes, bone loss is a known side effect of anastrozole and other aromatase inhibitors. Because these medications lower estrogen levels, they can reduce bone density over time — first leading to osteopenia (early bone thinning), and potentially progressing to osteoporosis (brittle bones).
Research also suggests that anastrozole may be more closely linked to bone fractures compared to other aromatase inhibitors, so your doctor is right to take this seriously and monitor it closely. Prolia (denosumab) is a medication commonly prescribed to help protect bone density in people on aromatase inhibitors. Many MyBCTeam members have discussed their experiences with it.
Some things worth knowing before starting Prolia:
- It's given as an injection every 6 months
- It can help slow bone loss caused by hormone therapy
- Some people report side effects like joint or muscle pain
- It's important not to stop Prolia suddenly without talking to your doctor, as this can temporarily increase fracture risk
It's always a great idea to ask your oncology team about what to expect and how your bone density will be monitored while on it. You're definitely not alone in navigating this!
June 13
@A MyBCTeam Member
Research all side effects of Prolia before making a decision.
Ask why Prolia was chosen.
Be aware of jaw necrosis…
Be sure to have a bone density test now if you have not had a DEXA scan before starting any AI if you do not have a reeent score.
There is a website where women discuss the side effects of these medications to stop osteoporosis.
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June 13 (edited)
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