Can you still experience side effects from aromatase inhibitors (AIs) if your ovaries were removed over 30 years ago?
The short answer is yes, you can still experience side effects from AIs even without ovaries. Here's why:
AIs work by blocking an enzyme called aromatase throughout your body, not just in the ovaries Show Full Answer
Can you still experience side effects from aromatase inhibitors (AIs) if your ovaries were removed over 30 years ago?
The short answer is yes, you can still experience side effects from AIs even without ovaries. Here's why:
AIs work by blocking an enzyme called aromatase throughout your body, not just in the ovaries. After menopause or oophorectomy (ovary removal), other tissues like fat, muscle, and adrenal glands continue producing small amounts of estrogen through this enzyme.
Common side effects of AIs include:
* Muscle and joint pain
* Hot flashes
* Bone thinning
* Fatigue
The muscle and joint pain can be severe enough that some people need to discuss alternative treatments with their doctor. These side effects happen because AIs lower estrogen levels throughout your body, regardless of whether you have ovaries.
If you're experiencing troublesome side effects from an AI, talk with your oncologist. They may be able to suggest pain management strategies or consider switching you to a different hormonal therapy option. Never stop taking your medication without consulting your care team first.
December 6, 2025
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