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I was put on that Calcium / Vitamin D3 regimen in preparation for starting Letrozole. It's to proactively counter potential side effect of bone loss from letrozole. The first day and subsequent two days after I had tremendous lower leg pain at night. I stopped and the leg pain is gone.

November 29, 2025 (edited)
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A MyBCTeam Member

Calcium carbonate is not a good form of calcium to take. It doesn’t get well absorbed. It’s better to get calcium citrate and take magnesium citrate or bisgycinate with it, as well as D3/K2. All of these need to be taken to make sure you have a good absorption into the bones and not the veins.

November 29, 2025
A MyBCTeam Member

I don't take any supplements, but I know I get a leg calf cramp if I
stretch my legs first thing upon waking in the morning. I'd rather have
labor pains! As far as my legs go like walking or standing for a log
time, I've had that problem for years but that's caused by my back
problems. Osteoporosis.. So I live with it.. Although I did run when yellow
jackets got mad and were chasing me.

November 29, 2025
A MyBCTeam Member

Be sure to take the D3 with K2 as that’s what deposits the calcium directly into the bones otherwise it goes to other areas in your body.

November 29, 2025
MyBCTeam

Have you experienced leg pain from calcium carbonate with vitamin D3 supplements while preparing for letrozole?

It's great that you're being proactive about bone health before starting letrozole. While calcium and vitamin D supplementation is commonly recommended to help prevent bone loss from aromatase inhibitors like Show Full Answer

Have you experienced leg pain from calcium carbonate with vitamin D3 supplements while preparing for letrozole?

It's great that you're being proactive about bone health before starting letrozole. While calcium and vitamin D supplementation is commonly recommended to help prevent bone loss from aromatase inhibitors like letrozole, leg pain from the supplements themselves isn't typically a widely reported side effect.

However, it's important to know that taking too much vitamin D can cause muscle weakness and pain, along with other side effects. The timing of your leg pain starting right after beginning the supplement and stopping when you discontinued it does suggest a possible connection.

A MyBCTeam member shared experiencing "pretty significant leg and hip pain" during their first six months on letrozole, though this was attributed to the medication itself rather than supplements.

What you should do:

Contact your doctor before restarting the supplements. They can:
- Check if the dosage might be too high for you
- Consider alternative formulations or schedules
- Rule out any interactions with other medications
- Possibly test your vitamin D levels

Your bone health is important for letrozole treatment, so work with your healthcare team to find a supplement plan that doesn't cause uncomfortable side effects.

November 29, 2025

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