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September 8, 2025
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Common side effects of letrozole include
• Joint and muscle pain
• Hot flashes and night sweats
• Sexual side effects like vaginal dryness
• Digestive issues including nausea and constipation
• Anxiety and depression
• Changes in weight
• Bone density loss

More serious but rare side effects that require immediate medical Show Full Answer

Common side effects of letrozole include:
• Joint and muscle pain
• Hot flashes and night sweats
• Sexual side effects like vaginal dryness
• Digestive issues including nausea and constipation
• Anxiety and depression
• Changes in weight
• Bone density loss

More serious but rare side effects that require immediate medical attention include blood clots, liver problems, and signs of heart problems or stroke. Hair loss is a notable concern with both medications. About 6% of people taking letrozole experience hair thinning and loss. Many find this particularly challenging, especially after regrowing hair following chemotherapy. One encouraging note is that some side effects may improve over time - for example, some people report joint pain decreasing after the first six months of treatment.

Remember to discuss any severe or concerning side effects with your healthcare provider, as they may be able to adjust your treatment plan or suggest ways to manage side effects.

September 8, 2025

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