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A MyBCTeam Member asked a question 💭
Kannapolis, NC

Hi, 67f here. Her2pos neu. I'm done with herceptin. Brain fog got bad during Letrozole. Does anyone have better suggestions for a hormone blocker. I understand I have 3-4 other pill options from my oncologist. They haven't sent that info yet. I don't want the effectiveness window closing since I stopped letrozole almost 4 wks now
Thanks

April 10, 2025
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MyBCTeam

For postmenopausal women with hormone receptor-positive breast cancer, anastrozole (Arimidex) is a common alternative to letrozole. Studies show that anastrozole has similar effectiveness to letrozole - the five-year disease-free survival rates are very close (82.9% for anastrozole vs 84.9% for letrozole).

Like letrozole Show Full Answer

For postmenopausal women with hormone receptor-positive breast cancer, anastrozole (Arimidex) is a common alternative to letrozole. Studies show that anastrozole has similar effectiveness to letrozole - the five-year disease-free survival rates are very close (82.9% for anastrozole vs 84.9% for letrozole).

Like letrozole, anastrozole is taken as a daily tablet with or without food. The overall survival rates between these medications are also comparable (89.2% for anastrozole vs 89.9% for letrozole). It's important to discuss your experience with brain fog with your oncologist, as they can help determine the best alternative medication based on your specific situation. Since you've been off letrozole for 4 weeks, scheduling an appointment soon would be beneficial to maintain continuous hormonal therapy and ensure the best possible outcomes for your treatment.

April 10, 2025

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