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The standard tamoxifen dose of 20mg daily was established when the drug was first developed in the 1960s, with the primary focus being on prevention rather than finding the minimum effective dose. Recent research suggests that even lower doses might be effective - a study found that just 5mg daily reduced breast cancer Show Full Answer

The standard tamoxifen dose of 20mg daily was established when the drug was first developed in the 1960s, with the primary focus being on prevention rather than finding the minimum effective dose. Recent research suggests that even lower doses might be effective - a study found that just 5mg daily reduced breast cancer recurrence by 52% compared to placebo. Tamoxifen works by blocking estrogen receptors rather than by lowering estrogen levels in the body. This means its effectiveness isn't directly related to body weight or estrogen production levels. The current dosing approach aims to ensure adequate blocking of these receptors, regardless of individual factors like weight or surgical history. While your question raises important points about personalized medicine, research shows that going above certain doses of tamoxifen won't produce additional benefits but may increase side effects. Scientists are still studying optimal dosing, as shown by recent research into lower-dose options that might maintain effectiveness while reducing side effects.

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