****Our AI did not read the complete article as it is in a stage 2 trial now.

Plus, for some reason, the AI thinks that we are in 2025, so that the article is fictional and has not happened. That is totally illogical.

****This is why AI should not be in complete charge of a human’s care.

“Researchers at the University of Calgary wanted to investigate whether adding niacin (vitamin B3) to standard cancer treatment could improve outcomes. Since investigational studies conducted in 2020 (and earlier), researchers already established the unique role of vitamin B3 in brain immune cells. Especially those related to the myelin sheet, a protective layer around the nerves.
In their phase I/II clinical trial, they examined the effects of niacin in patients with newly diagnosed glioblastoma. An interim analysis included 24 evaluated.”

This is ongoing.

Patients Without Cancer Progression After 6 Months
Source: Roldan Urgoiti et al. (2026). The comparison uses historical data rather than patients randomly assigned to a control group.
In other words, approximately 82 out of every 100 patients receiving the combination would be expected to remain free of disease progression at six months, based on the reported estimate, compared with approximately 54 out of 100 in historical data.

The researchers also reported a median progression-free survival of 10 months and a median overall survival of 17 months. Median overall survival means that half of the patients had died by that point, while the other half survived longer.
However, there is an important limitation. This was not a randomized controlled trial. Researchers compared their results with previously published data rather than a simultaneous control group. Consequently, we cannot conclude that niacin itself was responsible for the difference. Since vitamin B3 is a very benign substance with little to none side effects, it is important that patients consider this treatment option if they have been diagnosed with glioblastoma. “

*****This information is important to those breast cancer patients dealing with metastatic breast cancer which sometimes spreads to the brain.

@A MyBCTeam Member I submitted a report for your post- as at the last Ambassadors meeting a few of us mentioned AI not getting things quite right- so hopefully, someone will review and invite AI to 2026!

Mentioned Users

A MyBCTea...

The results could be wonderful for people with glioblastoma, which is what took my husband at age 60 because there weren't many treatments at all for brain cancer. That particular clinical trial is strictly focused on glioblastoma and how high-dose niacin can reactivate localized immune cells within the brain's environment. Glioblastoma is a primary brain tumor. It starts in the brain's own supporting cells (glial cells) and does not spread from anywhere else in the body.

If you look at the broader picture of vitamin B3 (niacin) derivatives and breast cancer metastasis, the relationship is highly complex, ongoing, and actually points in two completely opposite directions depending on the specific form of the vitamin:

The Harmful Link:
While the Calgary study looks at niacin as a cancer fighter, a highly publicized study from the University of Missouri found that a trendy, anti-aging form of vitamin B3 called Nicotinamide Riboside (NR) might actually increase the risk of triple-negative breast cancer (TNBC) and cause it to metastasize to the brain.
Cancer cells have a highly accelerated metabolism and aggressively consume energy to grow. Because NR is highly effective at boosting cellular energy (NAD+ levels), the breast cancer cells essentially "fed" off the supplement, gaining the energy required to break away and spread to the brain.

The Protective Link:
A separate line of research focusing on Nicotinamide (NAM)—another common form of niacin—showed potential in suppressing breast cancer metastasis.
In laboratory models of triple-negative breast cancer, NAM disrupted the cancer cells' mitochondria (their powerplants) and caused a massive overload of toxic reactive oxygen species (ROS). Instead of feeding the cancer, this specific compound triggered cancer cell death and heavily restricted the tumor's ability to spread. (NIH)

lol!! AI is too new to assume it’s all correct information. Just be careful using it.