I'm on Anastrozole and I'm also on Zepbound as well. I talked with my oncologist and my PCP, as I was very frustrated with gaining weight when I was trying so hard to lose weight.
October 30
Hi MIRIAM2, I'm on Anastrozole and I have started taking zepbound. So far only 9 pounds downs after 3 months but my doctor says I need to add exercise, so I will try harder.
October 30
Weight gain while on letrozole is a real and frustrating experience — you're definitely not alone in this! Some MyBCTeam members have shared similar struggles, with one noting they gained weight and then lost it suddenly, describing it as "weird." Regarding weight loss medications like GLP-1 shots (such as Ozempic), some Show Full Answer
Weight gain while on letrozole is a real and frustrating experience — you're definitely not alone in this! Some MyBCTeam members have shared similar struggles, with one noting they gained weight and then lost it suddenly, describing it as "weird." Regarding weight loss medications like GLP-1 shots (such as Ozempic), some cancer centers are actively researching their use for people managing weight during and after breast cancer treatment. However, it's really important to speak with your oncology team before starting any weight loss medication, as some treatments can interact with letrozole. In the meantime, here are some approaches that may help:
- Eat whole foods — fruits, vegetables, lean proteins, and whole grains
- Stay hydrated — drinking plenty of water supports your body's metabolism
- Exercise regularly — even light daily movement can make a difference
- See a registered dietitian — ask your doctor for a referral for personalized guidance The most important step is to bring this up with your oncology team. They can help identify the best and safest path forward for managing your weight while staying on track with your breast cancer treatment.
October 30
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