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Real members of MyBCTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone noticed if anastrozole makes you tired? I sleep quite a lot and I'm not sure why.

A MyBCTeam Member asked a question 💭
Zephyrhills, FL
September 30
 · 
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A MyBCTeam Member

All AIs and CDK inhibitors can leave you feeling drowsy, fatigued, and tired. Just having cancer can make you tired. If you have radiation or chemo they can make you tired. Surgery and recovery are tiring. Cancer is just tiring in general, both physically and mentally. I think most cancer patients get sick and tired of being sick and tired, but we trudge along as best we can. The best advice I can give is to listen to your body and let it be your guide. If possible rest when your tired and nap when your sleepy ❤️

October 3
MyBCTeam

Fatigue and sleep changes are commonly reported by people taking anastrozole. While excessive sleepiness isn't always listed as a top side effect, several factors related to the medication can affect your energy levels and sleep patterns.

Anastrozole works by significantly lowering estrogen levels, which can trigger a range Show Full Answer

Fatigue and sleep changes are commonly reported by people taking anastrozole. While excessive sleepiness isn't always listed as a top side effect, several factors related to the medication can affect your energy levels and sleep patterns.

Anastrozole works by significantly lowering estrogen levels, which can trigger a range of side effects that may leave you feeling drained, including:

- Joint and muscle pain — ongoing discomfort can be exhausting
- Mood changes — feeling low or irritable takes energy
- Night sweats and hot flashes — these can disrupt sleep quality, even if you don't fully wake up
- Vaginal dryness and discomfort — general physical discomfort adds up Poor sleep quality — even if you're sleeping a lot — can actually leave you feeling more tired. It's worth mentioning this to your care team, as they may be able to suggest ways to improve sleep quality or manage side effects that could be contributing to fatigue.

Many MyBCTeam members have shared similar experiences, so you're definitely not alone in this! 💙

September 30

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