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“ High histamine levels are increasingly recognized as a hidden driver of fibromyalgia and ME/CFS flares and other immune system problems.Excess histamine—often from overactive mast cells—crosses into the central nervous system, driving neuroinflammation, widespread pain, "fibro fog," and profound fatigue. [1, 2, 3, 4]
Managing this overlap usually requires an approach that reduces your total histamine burden and supports how your body processes it. [1]
1. Dietary Adjustments
Low-Histamine… read more
Answer Summary
Members connected over histamine reactions linked to breast cancer treatments, particularly aromatase inhibitors like Letrozole, sharing... Read more
What do histamine reactions mean for breast cancer patients, and how can they be managed?
Histamine is a chemical stored in white blood cells that regulates inflammation. When released, it can cause pain, allergic reactions, and widened blood vessels. For breast cancer patients, histamine reactions can be triggered by Show Full Answer
@A MyBCTeam Member
Sue, thanks for info that Exemestane may not activate histamines. I took it before Letrozole and had severe joint pain. I tried 3 AI; each problems. I think whatever onco has me take, I will ask for brand name only. Previous trys were all generic; fillers. I know I am very sensitive to any medication. Reading tells me brand name may be better; even different brands affect tolerance. Trial and error.
Appreciate all your informative posts.
Just a point of clarity: histamines are the mediator of allergic reactions. For instance if you have a bee allergy and get stung, the mast cells in your skin respond to the bee venom by releasing histamines into the tissues, and histamines then cause hives and all kinds of other allergy symptoms. There is a lot of new research going on related to how and why mast cells release histamines in the absence of an obvious allergic exposure. There is a relatively newly recognized condition called Mast Cell Activation Syndrome. As suggested already, there is a relatively easy and cheap way to assess this condition by taking 2 types of anti-antihistamines. I suspect this may not be on the radar of the average oncologist (yet!)
Sue, thank you for this info. I too had allergy testing done and am allergic to histamine. I’m on Claritin x2, and Zyrtec x2 and stomach acid reducer daily. Morning and evening. I buy them all generic at Costco for a dramatic savings. My hives are gone and so is itchy sneezing by 80% or so. I’m able to work and stay active. Some days better than others. I need rest and have stopped fighting it.
I’d does dry my mouth and causes more water consumption, so that’s a plus. As far as overall pain, I have all the same ailments that we all do from cancer, chemo, radiation, surgery and life🤣
I love you very much. Thank you for all the research and info sharing you do. 💝🥰💞💗🤗
@A MyBCTeam Member
Even though tomatoes are high in histamine, they seem to help me.
I have tomato soup, and there seems a big benefit warding off knee inflammation
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