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Real members of MyBCTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
October 20, 2025
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A MyBCTeam Member

So the estrogen levels will never be like they were before starting the hormone therapy?

October 20, 2025
MyBCTeam

Yes, joint and muscle pain can persist after stopping aromatase inhibitors. These medications work by lowering estrogen levels, which can lead to long-term effects on bone density and joint health. Aromatase inhibitor-induced musculoskeletal symptoms (AIMSS) commonly affect areas like the hips, hands, knees, back, and Show Full Answer

Yes, joint and muscle pain can persist after stopping aromatase inhibitors. These medications work by lowering estrogen levels, which can lead to long-term effects on bone density and joint health. Aromatase inhibitor-induced musculoskeletal symptoms (AIMSS) commonly affect areas like the hips, hands, knees, back, and shoulders. Some ways to help manage ongoing joint pain include:

• Regular physical activity and stretching
• Physical therapy
• Weight management (higher BMI is associated with increased joint pain)
• Acupuncture
• Daily walking routines

It's important to discuss persistent pain with your healthcare team, as they can help develop an appropriate management plan for your specific situation.

October 20, 2025

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Rochester, NY