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Real members of MyBCTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 20, 2025
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MyBCTeam

Letrozole (Femara) is a type of hormonal therapy called an aromatase inhibitor used to treat hormone receptor-positive breast cancer. It's typically prescribed after initial treatments like surgery, radiation, or chemotherapy and is usually taken for 5-10 years. The medication comes as a tablet that you can take with or Show Full Answer

Letrozole (Femara) is a type of hormonal therapy called an aromatase inhibitor used to treat hormone receptor-positive breast cancer. It's typically prescribed after initial treatments like surgery, radiation, or chemotherapy and is usually taken for 5-10 years. The medication comes as a tablet that you can take with or without food, but it's important to take it at the same time each day as prescribed by your doctor. Clinical studies have shown Letrozole to be highly effective, with about 85% of patients remaining cancer-free after 5 years of treatment. Common side effects you may experience include:

• Pain
• Hot flashes
• Decreased bone density
• Fatigue
• High cholesterol
• Sleep disturbances

It's important to discuss any concerns about potential side effects with your healthcare team, as they can often suggest ways to manage them effectively.

August 20, 2025
A MyBCTeam Member

I have been taking Letrozole since March 2023. The side effects seem to have calmed down but I still have night sweats. Think pretty significant hot flashes and night sweats plus hair thinning, ridiculously dry skin, hair and nails.

August 21, 2025
A MyBCTeam Member

Thank you Sue! Yes, always exercised. Hiking as well.

August 21, 2025
A MyBCTeam Member

@A MyBCTeam Member

I just checked your age and you are amazing.

I have been taken off the Letrozole at the 2 1/4 years point. The muscles both above and below the knees at about 2 inches and the right ankle were giving out without any notice and I was at high risk of falling. I had 2 close calls. One I would have fallen on cement and against my car.

I have been off it since July 7th.
Finally, the muscles are not doing that.

Towards the end of taking Letrozole, I developed neuropathy of feet and knees and plantar fasciitis and am still dealing with that.

I have an appointment at the end of September with my medical oncologist to decide what to do next.

Have you always exercised? What have you done to work through Letrozole successfully?

Super Hugs
Sue 💜

August 21, 2025
A MyBCTeam Member

I've been on letrozole for 2.5 years now, half of the 5 my dr prescribed. The side effects have subsided but I still get some joint pain 😢. I watch my bone density which has so far been OK 👍. I do take supplements. I intend to stick it out for the 5 years unless something changes for the worse.

August 21, 2025

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