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Aromatase inhibitors can be challenging for older adults who already have bone and joint conditions. These medications work by lowering estrogen levels by about 95%, which can further weaken bones and increase the risk of osteoporosis and fractures. For those who already have osteopenia, this is an important consideration Show Full Answer

Aromatase inhibitors can be challenging for older adults who already have bone and joint conditions. These medications work by lowering estrogen levels by about 95%, which can further weaken bones and increase the risk of osteoporosis and fractures. For those who already have osteopenia, this is an important consideration that should be discussed with their healthcare team. Joint pain and musculoskeletal symptoms are common side effects, affecting more than half of people taking these medications. For those with pre-existing arthritis, these symptoms may be more pronounced. The pain typically affects hands, knees, back, hips, and shoulders. Some people find these side effects severe enough that they need to stop treatment - studies show about 20% discontinue due to joint pain. It's crucial to discuss these pre-existing conditions with your healthcare provider. They can help monitor bone density, assess fracture risk, and develop strategies to manage side effects. Never stop taking these medications without consulting your care team first - they may be able to adjust dosages or suggest alternative treatments that better suit your individual situation.

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