This is my argument. I’m 67 years old, If my estrogen is already very low ( I had it tested before I started meds) then why would my dose be the same for younger women who are still producing more estrogen. Trust me I’m not saying g younger women should take more. My cancer was very tiny and have been told my odds of recurrence is 3% on meds but only 5%off meds. I’m on yet another two week reprieve from anastrozole because of the joint and muscle pains. Why can’t I take it every other day or a smaller dose. I get it !!! I don’t want the cancer to come back but living in this kind of pain daily is no fun. Women we are dammed if we do and damned if we don’t. The cancer that keeps on giving. Ugh

Anyone in this situation with AIMSS muscle skeletal syndrome needs the information on studies where lower doses were used.

Present these to your Dr. and have a discussion.

The important information to know is that the various AI’s have a certain time where they are still active in the body at day 2 or 3 without taking tablets on that day, namely Exemestane.
So one needs to know the active “shelf life”
In the body of the various AI’s.

I have been on all 3 of the AIs, tried different dosing schedules for the past 3+ years. The side effects have become intolerable for me and my oncologist doesn't have anything else to offer. Tamoxifen wasn't even in the picture as an alternative.

https://pmc.ncbi.nlm.nih.gov/articles/PMC835323....

Aromatase Inhibitor-Associated Musculoskeletal Syndrome: Understanding Mechanisms and Management

https://pmc.ncbi.nlm.nih.gov/articles/PMC8353230/

I’m on a 2 week pause from Anastrazole as I mentioned. Stopped Tuesday 6/9/26.

I’m already starting to feel better.

My joints aren’t as achy and it has only been 3 days off of it.