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Biopsy in May was HER2+ and hormone positive. Pathology from last week's mastectomy shows only HER2- and hormone positive. Feeling confused.

September 20, 2024
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A MyBCTeam Member

I think surgeons should know exactly how many pathologist actually are going to look at the tissue before final diagnosis. Just like there are usually 2 radiologist that read scans. Interpretation is important, what they see. I believe in all aspects of the medical field there is the possibility of error.

September 21, 2024
A MyBCTeam Member

Thank you, ladies! You bet I'm asking for clarification! It's just too weird and unsettling. Surgeon has already put in a call to the path lab and will call me after he talks to them. If needed, I will ask for retesting and I will keep you all updated. 🩷

September 20, 2024 (edited)
A MyBCTeam Member

But the tumor tests done from the surgery should never
switch from Her+ to HER- or vis versa.

That means that either the test was inaccurate, which should not happen or someone else’s information was reported.

Please check on this and ask for an explanation.

September 20, 2024
A MyBCTeam Member

Jen, this is a big difference in that it will affect your treatment and prognosis. HER2-positive bc requires antibody treatment while HER2-negative does not. Since they’re both hormonal, you’ll probably get hormone blockers for sure, but the HER2 distinction is extremely important. You may want to insist to get both the biopsy and path tissue retested by a different lab/hospital. I know sometimes it depends on what “part” of the sample they’re looking at. But either way, a lot of things change based on just this difference, so suuuuuper important for you, and your onco, to know! Wishing you well with all this!

September 20, 2024 (edited)

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