I am very familiar with nerlynx. I took it two different times. The first time I took 6 pills at once. I was told that is just how it is done. In about 2 weeks I was hospitalized for dehydration from diarrhea. I tried it again and am doing well on it. I am slightly weak and a little tired. The diarrhea is managable. The difference this time is, I started taking 1 pill for a week, then 2 pills the next week until I got to 6 pills. I also took budesonide, immodium and lomotil. I really think it depends on how this drug is administered!!! I have been on it since March.

I finished my year of neratinib in July. My biggest problem was diarrhea. I dealt with it and made it through. I could have taken more anti-diarrhea Meds along with it as recommended, but it constipated me. I opted to deal with the diarrhea. Your system may be different.
It actually wasn't terrible and I was willing to do anything for cancer not to show its ugly face again. I have dealt with it twice already.
Good luck !
Everyone is different, do what you feel best for you! 💞

Sorry, I can't help with this one.