It is my understanding that any cancer cells remaining after surgery may develop resistance to the initial HER2-targeted treatment. Neratinib was developed to overcome this resistance by targeting the HER2 signaling pathway in a different way than trastuzumab and other HER2-targeted agents.
My surgeon told me the herceptin doesn't cross the blood brain barrier but nerlynx would take care of that.

I did have herceptin and perjeta chemo first. Worst side effect with nerlynx is diarrhea. I took 6 pills at once as I was told too because that is how it is administered. I was hospitalized for dehydration. I tried it again in March and am doing well. I started on 1 pill for a week then titrated up to 6. I took budesonide for a month. It is a colon steroid. Immodium and lomotil as well. Now I only need 1 immodium. It matters how it is administered!!!

@A MyBCTeam Member - So you mind me asking if the MO gave a reason for going on the Nerlynx after taking the perjeta and herceptin? My Mo has talked to me about it but is not 100% sure since it was never tested with the perjecta. I have done alot of research and it seems like regardless of the 2% increased survival rate it does attach and lill the Her2 which is my main concern.

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A MyBCTea...

A friend is going to check to see if MD Anderson has any information re: using the Neralynx after taking both the herceptin and Perjeta and if the results were still 2% increased survival rate. Not sure if I should go on 😩

We’re you on herceptin and Perjeta before taking?
Can’t find any information about it being tested or used with both drugs. Just with the herceptin.
How are the side effects?