Connect with others who understand.

sign up log in
About MyBCTeam

What Is HER2?

Updated on February 01, 2022
Medically reviewed by
Mark Levin, M.D.
Article written by
Maureen McNulty

  • Understanding the genetic changes found in your breast tumor can help you and your care team design the most effective treatment combination.
  • Breast cancer cells that are HER2-positive contain high levels of HER2, a protein that encourages cell growth.
  • HER2-positive breast cancer cells tend to grow and spread quickly, but it can often be controlled and killed using targeted therapies.

Understanding which gene mutations your breast cancer cells have gives you and your cancer care team more information about your condition. About 20 percent of all cases of breast cancer are HER2-positive. Most breast cancers are HER2-negative, although researchers are also recognizing a newer category, HER2-low.

HER2 status is one of many factors of breast cancer that describe important characteristics of tumors and help predict how they will grow. Knowing your cancer is HER2-positive (also written as HER2+) helps your care team better predict your outlook and the treatments most likely to be effective.

The HER2 Gene

Genes often have very long, specific names. The full name of the HER2 gene is human epidermal growth factor receptor 2. This is often shortened to HER2 receptor, HER2/neu, or simply HER2. It also sometimes goes by other names, such as ERBB2.

The HER2 gene makes a protein that is also called HER2. When HER2 is activated (turned on), it sends signals to the cell, telling the cell to grow. The cell then begins preparing to divide and produce new cells.

In HER2-positive breast cancer, cell damage results in gene amplification, in which many extra copies of the HER2 gene are made. Larger numbers of HER2 genes lead cancer cells to make higher than normal levels of the HER2 protein. As a result, the cancer cells grow too quickly, forming a tumor. Knowing your cancer is HER2-positive helps doctors understand why your cells are growing abnormally and provides insights about how to treat the tumor.

Are you living with HER2-positive breast cancer?
Click here to share your experience or ask a question in the comments below.

Testing for HER2

If you are diagnosed with breast cancer, your care team will probably recommend you go through genetic testing to determine your HER2 status. This testing can be performed on your biopsy tissue or through a blood test. Genetic tests can also help your doctor see whether or not your cells have other cancer-related proteins, such as hormone receptors.

The first step of breast cancer diagnosis and HER2 testing is often getting a biopsy. During this procedure, doctors remove a sample of your breast tissue. The sample will then be examined using tests such as:

  • Immunohistochemistry (IHC), which estimates the amount of HER2 protein on the outside of your cells
  • Fluorescence in situ hybridization (FISH), which measures the number of HER2 genes inside your cells

Read more about diagnostic tests for HER2-positive breast cancer.

Treatments for HER2-Positive Breast Cancer

Individuals with all subtypes of breast cancer may need treatments like:

  • Surgery to remove the tumor and all or part of the surrounding breast
  • Radiation treatment to get rid of remaining cancer cells after surgery (called adjuvant treatment) or shrink the tumor before surgery (neoadjuvant treatment)
  • Chemotherapy medication to kill cancer cells throughout the body, which can be administered prior to surgery or after surgery
  • Hormone therapy, if the tumor is also hormone receptor-positive

Most people with HER2-positive breast cancer will receive targeted therapy. These medications can find and destroy any cell that contains HER2 protein. Targeted therapy drugs attach to HER2, preventing it from sending signals to the cell to tell it to continue growing. This eventually leads to death of the cell.

Read more about treatments for HER2-positive breast cancer.

How Does HER2 Affect Your Prognosis?

Breast cancers that are HER2-positive tend to grow more quickly than HER2-negative breast cancers. In the past, individuals with HER2-positive breast cancer often didn’t have a good prognosis, or predicted outlook for survival. However, newer treatments have helped many people with HER2-positive cancer have better outcomes. When using modern treatment plans, individuals with HER2-positive breast cancer can live longer. More than 3 out of 4 people with HER2-positive breast cancer live for over 10 years following their diagnosis.

Sometimes, after cancer is treated the first time, it can come back. This is known as a relapse. Targeted therapies for HER2-positive breast cancer help lower the risk of relapse.

Other factors may increase or decrease this risk of relapse, however. If the tumor is large or has spread beyond the breast, the cancer may be more likely to come back. On the other hand, individuals with tumors that are both HER2-positive and hormone receptor-positive may have a lower risk of relapse.

Talk With Others Who Understand

MyBCTeam is the social network for people with breast cancer and their loved ones. On MyBCTeam, members come together to ask questions, give advice, and share their stories with others who understand life with breast cancer.

Are you living with HER2-positive breast cancer? Share your experience in the comments below, or start a conversation by posting on your Activities page.

All updates must be accompanied by text or a picture.
Mark Levin, M.D. is a hematology and oncology specialist with over 37 years of experience in internal medicine. Review provided by VeriMed Healthcare Network. Learn more about him here.
Maureen McNulty studied molecular genetics and English at Ohio State University. Learn more about her here.

Related articles

The most advanced stage of breast cancer is stage 4 breast cancer, also called metastatic breast...

Stage 4 Breast Cancer: Treatment and Prognosis

The most advanced stage of breast cancer is stage 4 breast cancer, also called metastatic breast...
During a breast cancer diagnosis, your doctor will determine the stage of your cancer. Stages...

Navigating Treatments and Prognosis for Stage 3 Breast Cancer

During a breast cancer diagnosis, your doctor will determine the stage of your cancer. Stages...
Cancers, including breast cancer, are divided into stages, based on how far the cancer has...

Stage 2 Breast Cancer: Treatment and Prognosis

Cancers, including breast cancer, are divided into stages, based on how far the cancer has...
Breast cancer is classified into different stages ranging from 0 to 4. Staging is based on the...

Stage 1 Breast Cancer: Treatment and Prognosis

Breast cancer is classified into different stages ranging from 0 to 4. Staging is based on the...
At the time of breast cancer diagnosis, a doctor will determine the stage of the disease to help...

Stage 0 Breast Cancer: Treatment and Prognosis

At the time of breast cancer diagnosis, a doctor will determine the stage of the disease to help...
If you are living with breast cancer or care for someone who does, you’ve likely read quite a bit...

5 Facts About Breast Cancer That Aren't Well Known

If you are living with breast cancer or care for someone who does, you’ve likely read quite a bit...

Recent articles

Feelings of stress are common among people living with metastatic breast cancer.Managing stress...

Stress-Reduction Techniques for People Living With Metastatic Breast Cancer

Feelings of stress are common among people living with metastatic breast cancer.Managing stress...
Eating a healthy diet, getting regular physical activity, and taking steps to support your...

Living With Metastatic Breast Cancer

Eating a healthy diet, getting regular physical activity, and taking steps to support your...
Life following treatment for breast cancer can present new and unexpected challenges, including...

Breast Cancer Survival: Life After Treatment

Life following treatment for breast cancer can present new and unexpected challenges, including...
Researchers estimate that 90 percent of people with breast cancer experience fatigue during...

Managing Fatigue and Breast Cancer

Researchers estimate that 90 percent of people with breast cancer experience fatigue during...
Having conversations about breast cancer and its treatments can be confusing and overwhelming....

How To Talk To Your Doctor About HER2-Positive Breast Cancer

Having conversations about breast cancer and its treatments can be confusing and overwhelming....
When a routine breast exam or mammogram indicates the presence of thickened skin or a suspicious...

Breast Biopsy for Breast Cancer Diagnosis

When a routine breast exam or mammogram indicates the presence of thickened skin or a suspicious...
MyBCTeam My breast cancer Team

Thank you for signing up.

close