For some people, unwanted facial hair may affect self-esteem and cause embarrassment. Facial hair growth isn’t a commonly recognized side effect of tamoxifen (Soltamox), but some MyBCTeam members have noticed it while taking the drug.
One member asked, “Is anyone experiencing increased growth of facial hair since taking tamoxifen?”
The connection between tamoxifen and facial hair growth appears to be uncommon. But your personal experience matters.
Continue reading to learn what researchers know about the possible connection and ways to manage unwanted facial hair.
Tamoxifen is a hormonal therapy used to treat hormone receptor-positive breast cancer and to reduce breast cancer risk in some people at high risk.
Tamoxifen is a selective estrogen receptor modulator (SERM). It attaches to estrogen receptors on breast cancer cells, blocking estrogen signals that can tell the cells to grow and divide. This can slow or stop cancer cell growth.
Tamoxifen acts differently in different parts of the body. In breast tissue, it blocks the effects of estrogen. In bone, it can act more like estrogen, which may help limit bone loss after menopause.
Excess hair growth isn’t listed among the recognized side effects of tamoxifen. In fact, 1 percent to 10 percent of people taking tamoxifen experience the opposite effect — hair thinning or hair loss.
Other common side effects of tamoxifen include:
Serious side effects can include uterine changes, blood clots, and liver problems. Contact your care team right away or seek emergency care, depending on the symptom, if you notice any of the following:
Cleveland Clinic reports that more than 4 in 10 females will have excess facial or body hair called hirsutism at some point in their lives. Hirsutism causes coarse, dark hair to grow in areas that typically have finer hair, such as the face, chest, back, or upper arms and legs.
Higher-than-normal androgen levels are a common cause of hirsutism. Everyone has androgens, but higher levels can trigger coarse, dark hair growth in androgen-sensitive areas.
Many factors can contribute to facial hair growth, and the cause isn’t always easy to pinpoint.
Medical Conditions Hirsutism can be a sign of a hormone imbalance. Sometimes, an underlying medical condition is responsible.
Conditions that can cause hormone imbalances and excess facial hair include polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS), and adrenal tumors. Your healthcare provider may order blood tests and other exams to look for a possible cause.
Menopause Facial hair may also be more noticeable after menopause, when the ovaries stop making as much estrogen as before.
After menopause, estrogen levels fall. If androgen levels don’t fall as much, the balance between these hormones can shift, a change called relative hyperandrogenism.
Breast cancer treatment can cause menopause to start early. Chemotherapy and hormonal treatments such as tamoxifen can also trigger symptoms associated with menopause.
People who were using hormone replacement therapy (HRT) before a breast cancer diagnosis may notice menopause symptoms if they stop HRT. Ask your healthcare team whether HRT is appropriate for you after breast cancer.
Medications Many medications can also cause excess hair growth. These include:
Cyclosporine and phenytoin are more likely to cause excessive hair growth over larger areas of the body. This is called hypertrichosis.
Hypertrichosis isn’t the same as hirsutism. Hirsutism tends to affect distinct areas, such as the face, chest, back, upper arms, and inner thighs.
Tamoxifen has been linked to hirsutism, but exactly why this may happen isn’t clear. StatPearls lists estrogen antagonists such as tamoxifen among medications that can cause hirsutism.
Hirsutism appears to be uncommon with tamoxifen. It also isn’t listed as an adverse reaction in the Soltamox prescribing information.
One case report described a woman who developed coarse hair on her face, arms, and shoulders within eight weeks of starting tamoxifen. Her hirsutism improved after her care team switched her from tamoxifen to another hormone therapy. A single case report can’t prove that tamoxifen causes facial hair growth.
On MyBCTeam, people share their experiences with breast cancer, get advice, and find support from others who understand.
Have you experienced facial hair growth or other unexpected changes while taking tamoxifen? Let others know in the comments below.
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