MyBCTeam

First — two years with no signs of cancer on stage 4 inflammatory breast cancer is genuinely remarkable. That's worth acknowledging! 🎉

Regarding enlarged spleen and high bilirubin while on Enhertu — these aren't among the most commonly reported side effects, but Enhertu is known to affect liver enzymes (ALT, ALP, and AST) Show Full Answer

First — two years with no signs of cancer on stage 4 inflammatory breast cancer is genuinely remarkable. That's worth acknowledging! 🎉

Regarding enlarged spleen and high bilirubin while on Enhertu — these aren't among the most commonly reported side effects, but Enhertu is known to affect liver enzymes (ALT, ALP, and AST), which can be related to bilirubin changes.

Some known side effects to be aware of with Enhertu include:

- Increased liver enzymes
- Low blood counts (white blood cells, platelets, neutrophils)
- Fatigue and nausea
- Lung inflammation (a serious risk requiring prompt attention)
- Heart function changes

Even without symptoms, elevated bilirubin and an enlarged spleen are worth discussing closely with your oncologist. These could be treatment-related or worth monitoring carefully given your history.

Other MyBCTeam members have shared experiences with unexpected lab changes while on Enhertu, so you're not alone in navigating these surprises.

Bringing specific lab results to your care team is the best next step — they can determine whether a dose adjustment or further investigation is needed.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Treatments

Enhertu