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Is anyone taking Letrozole in the morning instead of night? Also what do you do when you skip a dose?

A MyBCTeam Member asked a question 💭
Alpharetta, GA

I recently traveled out state for a week. My first trip away in 18 months. I was a bit frazzled with adjusting to travel and time zones etc and missed taking Letrozole at night. I took it the next morning and have been taking it at that time since.

June 18
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Answer Summary

Members responded to a question about taking Letrozole or Anastrozole in the morning instead of at night, with many sharing that switching to... Read more

Members responded to a question about taking Letrozole or Anastrozole in the morning instead of at night, with many sharing that switching to daytime helped reduce side effects like hot flashes and insomnia. Several members described their personal timing adjustments, including morning, noon, and evening doses, with many noting that taking it at night made sleep problems worse. A recurring theme was finding what works best for your own body, using phone alarms to stay on track, and skipping a missed dose if too many hours have passed rather than doubling up.

A MyBCTeam Member

@A MyBCTeam Member
I also suffer from insomnia. I have tried taking Letrozole at different hours . Take it at night makes my insomnia worse. I tried not to take Letrozole with my other meds, I found that noon time works best for me.
Good luck!
Sending hugs and prayers

June 19
A MyBCTeam Member

Hi! I take Anastrozole, for 14 months now. Initially I was taking it at night. I had hot flashes many times a day. My medical oncologist suggested taking it in the morning. I had fewer hot flashes when I switched. Now, more than a year later, I have 2 or 3 a day only - progress!

June 18
MyBCTeam

First of all, congrats on the trip — 18 months is a long time, and you deserved that getaway! It's completely understandable to get a little frazzled with travel and time zones.

You're definitely not alone in switching to morning doses. Several MyBCTeam members have made the same switch, especially to help with sleep. One Show Full Answer

First of all, congrats on the trip — 18 months is a long time, and you deserved that getaway! It's completely understandable to get a little frazzled with travel and time zones.

You're definitely not alone in switching to morning doses. Several MyBCTeam members have made the same switch, especially to help with sleep. One MyBCTeam member shared that taking letrozole first thing in the morning made a big difference for their sleep quality. Letrozole can cause side effects that disrupt sleep, including:

- Hot flashes and night sweats
- Nausea
- Dizziness
- Frequent urination
- Pain that makes finding a comfortable position difficult

Switching to a morning dose can help reduce these nighttime disruptions for some people. As for missing a dose, the most important thing is consistency — taking it at the same time each day matters most. What you did (taking it the next morning and sticking with that time) is a reasonable approach, but it's always best to check with your doctor or pharmacist about their specific guidance for missed doses, just to be safe.

June 18
A MyBCTeam Member

I've had insomnia as far back as I can remember, which is when I was about 6 years old. I asked my doctor when it would be best for me to take Letrozole. She said to take it in the morning. It still effects my sleep. I go to bed 2-3 hours later than I used to and I'm getting 1-2 hours less sleep each night since starting the Letrozole. When I miss a dose if it's only a couple of hours late I will take the pill. If too many hours have passed then I skip the pill for that day and start taking it again the next morning at the normal time I take all of my morning meds.

June 19 (edited)
A MyBCTeam Member

Hello. I’ve been on letrozole for more than five years. I take it every night at 6 p.m. I have a lot of side effects but since I am high risk I have to stay on it

June 18

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