I’m on anastrozole and other than being easily annoyed and overly emotional, which has been fixed with Lexapro, I haven’t really had any. Also have lupus and ra and didn’t need to change any medication. Recently started cream for vaginal dryness. All good here. Wishing you positive outcomes 😊

Hi Michelle. I only had a few hot flashes when I first started then they eased up. I’ve been on Anastrozole since March of 2025. When I hit the 1 year mark I started having more side effects, which I found out happens to some people at the 1 year mark. I missed a few days, not on purpose, but felt much better on those days. After discussing it with my oncologist she said because of my dx and low chance of reoccurring it was ok to only take it every other day. There are options if you have bad effects. Good luck!

Thank you, such valuable input!

I am on Letrozole and have been for 6 months now. For me the side effects started after about 10-14 days. The only side effects I have so far are hot flashes and my lifelong insomia has gotten worse. It's only a small percentage of people that have hair loss issues. I looked it up online and it says 3.4-6.25% of Letrozole users experience hair thinning or loss. I looked up joint pain too and what I read stated up to 50% of women experience joint pain on Letrozole. There are several different AI medications. You can try one and see how it goes and if you get intolerable side effects you can try another AI inhibitor and see if it agrees with you better. Another thing that can be tried is reducing the dose of the AI and see if that helps with side effects too. I've been told that I need to be on AIs for the rest of my life so I asked my doctor if I could take the lowest dose possible and she said that was fine so that's another option as well.

i have estrogen cream and vaginal suppositories....onc is aware