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October 28, 2025
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MyBCTeam

Is there any benefit to taking anastrozole for more than 5 years after 5 years of tamoxifen?

The available information doesn't specifically address extending anastrozole beyond 5 years after completing tamoxifen. However, here's what's generally known about hormonal therapy duration:

Breast cancer survivors are typically Show Full Answer

Is there any benefit to taking anastrozole for more than 5 years after 5 years of tamoxifen?

The available information doesn't specifically address extending anastrozole beyond 5 years after completing tamoxifen. However, here's what's generally known about hormonal therapy duration:

Breast cancer survivors are typically advised to take hormonal therapy like tamoxifen for at least 5 years to reduce recurrence risk. For early-stage breast cancer, treatment may last 5-10 years, while advanced breast cancer may warrant longer use if benefits outweigh side effects.

Switching from tamoxifen to an aromatase inhibitor like anastrozole is common for postmenopausal women. These medications work differently - anastrozole stops estrogen production entirely, while tamoxifen blocks estrogen from attaching to cancer cells.

The decision to extend anastrozole beyond the standard timeframe should be based on:
* Your individual cancer characteristics (tumor size, lymph node involvement, hormone receptor status)
* Your response to treatment
* Side effect tolerance
* Overall quality of life

This is definitely a conversation to have with your oncologist. They can evaluate your specific situation, weigh the potential benefits of continued protection against recurrence versus side effects, and help you make an informed decision about your treatment plan.

October 28, 2025
A MyBCTeam Member

Estertest is what gave me breast cancer. I was on leterzole for 10 years after chemo and radation

November 1, 2025 (edited)
A MyBCTeam Member

Maybe. There is test called BCI, Breast Cancer Index. It tests the the surgical tumor, and tells if you would benefit from another 5 years of anti estrogen therapy. I know of people that take beyond 10 years. There is no research to support this.

November 1, 2025
A MyBCTeam Member

The key thing to do while on an AI is take a supplement that is for immune health. You want your body to be able to recognize and kill off any cancer cells. Don't wait to do this after 5 years is up, do it starting now. And even though weight loss is hard while on these drugs, choose a plan to get rid of body fat because estrogen is manufactured in our body fat.

November 1, 2025
A MyBCTeam Member

Very hard decision Jan. If your cancer is estrogen dependent and you don't take anything to deplete that estrogen it opens the possibility of cancer coming back. Often cancer cells go into dormancy and are able to survive treatments and they will come out when the coast is clear. This is troubling because every woman who has completed 5 years of taking a drug meant to suppress estrogen are on their own when 5 yrs is done. It is also said if women stay on the drug for 5 years, the drug will protect them another 1-2 years. But then what happens ? Just have to hope all dormant cells are gone and that your body has a good immune system that will recognize a bad cell and destroy it.

November 1, 2025

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