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Does anyone have experience or up to date information about testosterone replacement with anastrozole in ER+ PR+ HER2 BC?

A MyBCTeam Member asked a question in Hormone Therapy group 💭
Scottsdale, AZ
September 19, 2025
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A MyBCTeam Member

The last thing you should do is add testosterone!!! HER2-ps bc often has testosterone receptors. So you’d be feeding your cancer directly. And testosterone also interacts and can transform into estrogen. Do not use ANY hormones with cancer. They all can promote growth and recurrence. That’s why the oncologist said no.

September 22, 2025 (edited)
A MyBCTeam Member

I had just started testosterone injections. I asked if it would be safe for me to start it back up again after I’m done with the radiation and while taking the anastrasole. My oncologist said no. Anything that can alter your hormones is not recommended. I’m not happy about it since I had just started to feel pretty good before I got diagnosed. But then neither one of us are happy to have to go through this now. So I just decided it is not worth the risk. Hope that helps. Hugs! 🤗

September 22, 2025
MyBCTeam

For hormone receptor-positive breast cancer (ER+/PR+), anastrozole works as an aromatase inhibitor to reduce estrogen production. It's typically prescribed for postmenopausal women as part of hormonal therapy for breast cancer treatment.

The medication should be taken exactly as prescribed by your doctor, usually as a Show Full Answer

For hormone receptor-positive breast cancer (ER+/PR+), anastrozole works as an aromatase inhibitor to reduce estrogen production. It's typically prescribed for postmenopausal women as part of hormonal therapy for breast cancer treatment.

The medication should be taken exactly as prescribed by your doctor, usually as a daily tablet that can be taken with or without food. It's important to take it at the same time each day for consistency. Given the complexity of hormone receptor-positive breast cancer treatment, any consideration of testosterone replacement therapy should be carefully discussed with your oncology team. They can evaluate your specific situation and determine if such a combination would be appropriate or potentially risky for your particular case.

Treatment decisions should always be made as part of a shared decision-making process with your healthcare team, taking into account your specific cancer characteristics and treatment goals.

September 19, 2025

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