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I was on anastrazole for two years and changed because of the extreme leg pain. Six months on letrizole and the pain is bad again but also in my arms and hands. I understand the third option is exemestane but it says the side effects are the same and I can’t afford the monthly cost of $300. Thanks,for any ideas.

May 3, 2025
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A MyBCTeam Member

I have had a couple of bad falls while on anastrazole because of leg pain and cramps. What my oncologist told me was to walk, the more one walks the less the pain. Some days are worse than others but walking and drinking more water reduced the symptoms for me.

May 4, 2025
A MyBCTeam Member

Hi Sue, not surprised at all you are having pain from the AI's. I found nothing that works. My leg stiffness/joint pain didn't start until the 5th months and worsened by the 7th month and then I stopped taking it for a month. Now, a year and a half later still have leg pain but not as bad but bad enough that I rather stop taking it soon so I can have my pain free legs back. I honestly don't know what to tell you as many women stop for the same reasons and just take their chances. ❤️

May 4, 2025
A MyBCTeam Member

@A MyBCTeam Member

I switched from Letrozole from
Breckinridge manufacturing to Letrozole from Accord manufacturing

You need to ask your Medical Oncologist to write you a new prescription that says Letrozole, Accord manufacturing only.

The Accord brand can be gotten from
Walgreens. It seems not as bad as the other manufacturers and has been recommended by British women on a British BC site.

May 3, 2025
A MyBCTeam Member

So many women stop the AI'S, I wonder how often oncologists deal with this. Clearly a certain amount of their patients stopped these drugs so they can deny the reported side effects all they want but they know.

May 5, 2025
A MyBCTeam Member

I took anastrozole for 2 weeks. I was given permission by the doctor to go off for 2 weeks to see how I felt. I had the same side effects as you. Then at my appointment I was offered other medications but I'm choosing to take none. My risk of cancer returning only lowered by 3% on the meds so I decided it wasn't worth taking the meds for a 3% difference. Quality of life is more important at this point in my life.

May 5, 2025

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Rochester, NY