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Real members of MyBCTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
February 26, 2025
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A MyBCTeam Member

I got endometrial cancer after taking Tamoxifen for 2 years followed by a radical hysterectomy. I, too, started bleeding heavily.

December 9, 2025
A MyBCTeam Member

I started having issues in October of 2023. I was done with my 5 years of tamoxifen on November 1, 2023. D&C in December 2023. HEAVY bleeding after that, and was put on yet another drug to try and help. But I could only take it for 5 days once a month. Wasn't enough to control it. Ended up having a total hysterectomy last May. Final results were polyps and endometriosis from the 5 years of tamoxifen. I know personally 2 others with similar experiences. I remember my surgeon and oncologist saying the risks were very low. But from personal experiences from myself and others tell me otherwise. Was just curious about the general public in this community as well.

February 27, 2025
A MyBCTeam Member

I have thicken wall measuring 17mm biopsy scheduled in April. No pain no bleeding so confused 3+ Breast cancer stage 3 in 2018 took tamoxifen for 5 years now taking nothing

February 26, 2025
MyBCTeam

Yes, some people taking tamoxifen experience endometrial issues. The medication can cause changes in the uterus, including polyps, fibroids, or thickening of the uterine lining. While these changes are often not cancerous, they may lead to abnormal bleeding or spotting that should be monitored by your healthcare team. If Show Full Answer

Yes, some people taking tamoxifen experience endometrial issues. The medication can cause changes in the uterus, including polyps, fibroids, or thickening of the uterine lining. While these changes are often not cancerous, they may lead to abnormal bleeding or spotting that should be monitored by your healthcare team. If you experience bleeding issues while on tamoxifen, your doctor may recommend screening tests like transvaginal ultrasounds or endometrial biopsies to check for any abnormalities. These are routine monitoring procedures that many people undergo while on tamoxifen treatment.

For those who are finished having children or experiencing significant bleeding issues, a hysterectomy might be recommended as a treatment option. This procedure will stop menstrual periods and abnormal bleeding permanently, though it does mean you won't be able to become pregnant afterward. While these concerns might sound worrying, it's important to note that serious complications are rare. The risk of developing endometrial cancer from tamoxifen is very low - only about 1 in 500 people taking the medication. However, always report any unusual bleeding or spotting to your healthcare team so they can properly evaluate your symptoms.

February 26, 2025

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