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Real members of MyBCTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I'm being treated with verzenio and also anastrozole.

February 25, 2025
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A MyBCTeam Member

Immunohistochemistry (IHC) test: This test measures the amount of HER2 proteins found on breast cancer cells. The score will either be 0 to 1+ (HER2 negative), 2+ (borderline) or 3+ (HER2-positive).

A lot of times if the test comes out as a 2+, they will retest with a different test called a FISH,

The FISH (fluorescence in situ hybridization) test checks the DNA of your cancer cells for extra copies of the HER2/neu gene. The result is then reported as positive or negative.

Hugs!

February 25, 2025
A MyBCTeam Member

My surgeon said they could not confirm the stage until after surgery, if there were no surprises, I would be a Stage 2.

They had done a needle core biopsy, and with that they were able to determine I was HER2+, and Grade 3 aggressive. The small sample they took of the closest lymph node was clear. The only difference between the imaging and biopsy was that the tumor was slightly larger than originally thought (measured on imaging as 2.5 cm, but was 2.7).

February 25, 2025
A MyBCTeam Member

Thanks Virginia for all the information. I failed to ask about the stage when I saw my doctor. I'll have to ask next time. I think it is stage 2. The cancer had not spread beyond my chest. (Between my right and left breast) my left breast is an implant.

February 25, 2025
MyBCTeam

Invasive lobular carcinoma (ILC) means that cancer cells which started in your breast's milk-producing glands (lobules) have begun to spread into nearby breast tissue. ILC is actually the second most common type of breast cancer, accounting for about 10% of invasive breast cancers.

The term "2+ IHC HER2" refers to your Show Full Answer

Invasive lobular carcinoma (ILC) means that cancer cells which started in your breast's milk-producing glands (lobules) have begun to spread into nearby breast tissue. ILC is actually the second most common type of breast cancer, accounting for about 10% of invasive breast cancers.

The term "2+ IHC HER2" refers to your HER2 status, which is an important marker that helps determine your treatment approach. A 2+ result typically means borderline or equivocal HER2 expression, and your healthcare team may do additional testing to confirm your HER2 status. Your current treatment combination of Verzenio (a targeted therapy) and anastrozole (a hormone therapy) suggests your cancer team is taking a comprehensive approach to your treatment. The prognosis and treatment effectiveness can vary depending on your specific hormone receptor status and other factors. It's important to maintain open communication with your oncology team about how you're responding to these medications and any side effects you may experience.

February 25, 2025

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