hi @Zgfighter-
For the first two weeks I was taking 5 MG of oxybutynin TWICE a day, and I was finding that the side effects (very dry mouth/nose/eyes, sore throat, extreme thirst) was negatively impacting my days to the point that I couldn't see the benefit. I then reduced to just a ONCE a day 5 MG dose (I take in the morning), and now I am doing really well. I do still have some dryness/thirst, but it is tolerable. And the hot flashes have improved; still there but with some less frequency and intensity. So, I'm scoring the combo of letrozole with one 5 MG dose of oxybutynin as a WIN and will continue to monitor.

Interesting use of oxybutenin. I also have been prescribed that for bladder incontinance, but i see if may be used for sweating isses. How is it working for you?

update: Opted to try the oxybutynin.
Only been on it a few days now so will provide updates in a bit as to whether it a) helps reduce the intensity and frequency of hot flashes, and
b) doesn't introduce any new intolerable side effects

we keep learning and trying

@A MyBCTeam Member: My primary care doctor diagnosed me with depression and mild anxiety after treatment for BC. She prescribe Venlafaxine for those symptoms and the 'happy' side effect was a reduction in the number and severity of hot flashes I was experiencing due to Tamoxifen. I take 75 mg Venlafaxine daily, which I believe is the mild dose, and have had no side effects (other than hot flash relief).

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A MyBCTea...

I started taking a mild dose of Venlafaxine about a month before I started Letrozole. At that time, I was experiencing side effects of mild anxiety during radiation, and my Oncologist suggested the Venlafaxine and said it also might be helpful for the side effects of Letrozole ( which I would soon be starting ).

My hot flashes with Letrozole were tolerable, and only lasted about 6 weeks. My hot flashes were mainly at night.