Most docs don't want to do it because they make more money on six weeks. If you qualify- go for it. My onc highly recommended it-- said she would do that herself!

For all infusions (I'm HER2+ ER/PR- and did TCHP (they tacked perjeta onto mine) every 3 weeks for 6 infusions. My experience:

Day of and day after were fine--for all six infusions (steroids had me good and hopped up). Mid-day 2 days after infusion, though, it hit me. My side effects changed with each infusions (eg: I only had to lose the hair one time--took care of that about 14 days after the first infusion, mouth sores only with first infusion, nausea only with 4th infusion, nose bleeds only with second infusion, muscle pain worst with last couple infusions, reacted to only the first Neulasta shot, and neuropathy didn't hit me until a couple months after the last infusion). However, Chernobyl mouth (that taste!), fatigue, and diarrhea were consistent throughout, and I'd get hit with a weird bit of something from the list above each time. Those would last a day or two after the first couple infusions and stretched out to last most of a week with the last one. (But it was the last one, so I wasn't too bothered by that.... I do remember feeling ripped off that I couldn't taste my food by day 5--thought that was a bit of a rip-off. :-)

Good part was I ALWAYS had at least 2 good weeks between infusions. More good than bad, definitely.

Oh, the chemo brain..... That one sort of hangs around with you through the entire process. I felt really tipsy in the week following any infusion, and by the end I couldn't find common words for things anymore (and would just blurt out nonsense--my kids thought it was hilarious. I did, too. It was just really interesting to me.) That one's going to hang on to some extent for awhile post your last infusion--can take a couple years to get back up to full mental function for some people--but I was doing much, much once the poison had been out of me for 6-8 months.

For me, side effects were fairly consistent throughout, and, as @A MyBCTeam Member indicates, you'll be able to predict somewhat which days will be good and which bad within your cycle. Fatigue, however, was absolutely cumulative, and this somehow made the other SI's more grueling as tx went on.
Listen closely to your body, sister soldier, and ease up when it tells you to do so.

((Hug))

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A MyBCTea...

They stay the same. You will have good days where you feel almost normal💜

I felt like the chemo effects were cumulative. First 2 treatments, only had headache and fatigue. Third chemo treatment...nausea, vomiting, flu like aches, bone pain. Fourth treatment...fatigue, headache, sporadic nausea.