I take Femara and don't have the side effects. I take it before I go to bed at night.

I was taken off Arimidex due to horrible side effects including a daily non-stop pounding headache. I have been on Femara/Letrozole for 2yrs now and still deal with the muscle/bone/joint pain but it is tolerable and alot less painful than the Arimidex.

Experienced same problems with Arimidex after 2.5 yrs. Surprising enough I switched to Femara which has the same possible side effects, and after the second month of taking it,some of the symptoms have lessened. Who would have thought!

I was put on Femara last April & stayed on it until 3 months ago when I was switched to Arimidex. Both drugs make my joints & bones ache. I'm lucky if I can make a fist in the morning when I wake up. I'm ready to call my oncologist to see about trying something else. Does everyone have to take a calcium & vitamin D supplement? Are there other supplements that are helpful. I also learned not to take the Calcium that is made with soy because that promotes estrogen. Need the one that is made with oyster. I feel like I've aged many years just this last year.

I was taken off Arimidex due to terrible side effects that I was experiencing, and put on Femara...thank goodness, I have not had any of those same effects from the Femara. Of course, everyone is different, so each experience is different also. I hope that you find one that will fit you with minimal side effects...best of luck, and hugs, Lisa!