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Truqap (capivasertib) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat some adults with breast cancer.
These insights are based on 51 comments about Truqap from MyBCTeam members. These are the experiences of a small number of individuals and are not meant to be medical advice.
Benefits:
Considerations:
Truqap is a type of medication called a kinase inhibitor. It works by blocking proteins called AKT, which can help cancer cells grow and survive.
In some people with hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2-negative (HER2-negative) breast cancer, changes in the PIK3CA, AKT1, or PTEN genes can make the AKT pathway more active. By blocking AKT proteins, Truqap may help slow the growth of cancer cells.
Doctors prescribe Truqap with fulvestrant when certain adults have HR-positive, HER2-negative breast cancer that is locally advanced or metastatic. The cancer must have a PIK3CA, AKT1, or PTEN gene change found by an FDA-authorized test.
Truqap is used after the cancer gets worse on at least one endocrine-based treatment for metastatic cancer, or if the cancer comes back on or within 12 months after finishing adjuvant therapy.
Truqap is a tablet taken by mouth. It can be taken with or without food.
Swallow Truqap tablets whole. Do not chew, crush, or split tablets before swallowing. Do not take tablets that are broken, cracked, or otherwise not intact.
Treatment continues until the cancer gets worse or side effects become unacceptable.
Typical Dosing for Breast Cancer
The recommended dose of Truqap for breast cancer is 400 milligrams taken by mouth two times a day, about 12 hours apart, for four days in a row, followed by three days without treatment each week. Truqap is used together with fulvestrant.
Treatment usually continues until the cancer gets worse or side effects become unacceptable.
Your healthcare provider may temporarily stop treatment, lower your dose, or permanently stop Truqap if certain side effects occur.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 51 comments about Truqap from MyBCTeam members.
Members who use Truqap often talk about preparing for side effects, keeping a close eye on symptoms, and staying in touch with their oncology team. Many also mention that dose changes, blood sugar checks, and follow-up scans or labs can be important parts of the treatment experience.
Prepare for diarrhea and nausea early.
“My biggest side effect has been diarrhea with some nausea in the first couple weeks.”
Tell your doctor right away about rash or severe itching.
“I developed a bad rash all over my body! I was on Truqap for only a week. The rash was so bad I couldn’t even sit down!”
Keep up with blood sugar checks and lab work.
“I have started Truqap. I had read and was told the side effects could be a lot, so I prepared ahead of time. I changed my diet, paid attention to when and how much I ate, followed a low-sugar diet, and checked my blood sugar at home.”
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In a clinical study of Truqap used with fulvestrant for adults with hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer with one or more PIK3CA, AKT1, or PTEN alterations, the most common side effects occurred in at least 20 percent of people taking Truqap with fulvestrant.
These side effects include:
Truqap can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
AstraZeneca, the manufacturer of Truqap, offers the Truqap Co-Pay Savings Program through AstraZeneca Access 360. Eligible people with commercial insurance may pay as little as $0 per month in out-of-pocket costs for Truqap.
AstraZeneca Access 360 can help answer questions about insurance coverage, out-of-pocket costs, and patient assistance programs. To learn more, visit the Truqap financial support page or call 844-275-2360.
Before starting Truqap, your doctor will test or check for:
Tell your doctor if you have had a severe allergic reaction to capivasertib or any ingredients in Truqap. Do not take Truqap if you have had a serious allergic reaction to capivasertib or any of its ingredients.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Before taking Truqap, tell your doctor about all of your medical conditions, including if you have:
Truqap is also FDA-approved, in combination with abiraterone and prednisone, to treat certain adults with PTEN-deficient metastatic androgen pathway modulation-naïve or -sensitive prostate cancer.
If you miss a dose, take it within four hours of when you usually take it. If more than four hours have passed, skip that dose and take your next dose at the usual time. If you vomit after taking a dose, do not take an extra dose.
Truqap can harm your baby if you are pregnant. Females who can become pregnant should use effective birth control during treatment and for one month after the last dose.
Males with female partners who can become pregnant should use effective birth control during treatment and for four months after the last dose.
Do not breastfeed during treatment with Truqap.
These answers are fact-checked by our editorial staff.
How effective is Truqap?
In a clinical study of people with HR-positive, HER2-negative locally advanced or metastatic breast cancer whose tumors had PIK3CA, AKT1, or PTEN alterations, people who received Truqap plus fulvestrant lived a median of 7.3 months without their cancer getting worse. People who received placebo (an inactive treatment) plus fulvestrant lived a median of 3.1 months without their cancer getting worse.
Among people with measurable tumors, 26 percent of those who received Truqap plus fulvestrant had their tumors shrink, compared with 8 percent of those who received placebo plus fulvestrant.
At the time of the analysis, overall survival results were not yet mature enough to draw conclusions.
How long does Truqap take to work for breast cancer?
Clinical studies did not measure the exact amount of time it takes for Truqap to start working. Instead, researchers looked at how long people lived before their cancer grew or spread further.
In a study of people with HR-positive, HER2-negative locally advanced or metastatic breast cancer with PIK3CA, AKT1, or PTEN alterations, those who received Truqap plus fulvestrant lived a median of 7.3 months without their cancer getting worse, compared with 3.1 months for those who received placebo plus fulvestrant.
Because people can respond differently to treatment, the amount of time it takes for Truqap to start working may vary from person to person.
Can Truqap interact with other drugs?
Yes. Truqap can interact with certain medicines, which may affect how well it works or increase the risk of side effects.
Before starting Truqap, tell your healthcare provider about all medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.
Some medicines can change the amount of Truqap in your body. In particular, medicines that affect an enzyme called CYP3A can interact with Truqap. Your healthcare provider may recommend avoiding certain strong or moderate CYP3A inhibitors or CYP3A inducers while you are taking Truqap.
In some cases, your healthcare provider may adjust your Truqap dose. Do not start, stop, or change any medicines without talking to your healthcare provider first.
On MyBCTeam, people share their experiences with breast cancer, get advice, and find support from others who understand.
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