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September 24
Anastrozole is a hormone therapy used to treat hormone receptor-positive breast cancer. Because it works by significantly lowering estrogen levels in the body, many of its side effects are related to that drop in estrogen.
Here are the most commonly reported side effects:
- Hot flashes
- Night sweats
- Joint stiffness or Show Full Answer
Anastrozole is a hormone therapy used to treat hormone receptor-positive breast cancer. Because it works by significantly lowering estrogen levels in the body, many of its side effects are related to that drop in estrogen.
Here are the most commonly reported side effects:
- Hot flashes
- Night sweats
- Joint stiffness or aching
- Muscle pain
- Bone thinning (osteoporosis)
- Vaginal dryness
- Pain during sex
- Fatigue
- Mood swings
- Weight changes Weight gain can be particularly frustrating. One MyBCTeam member shared, "Anastrozole and its alternatives make it very hard to lose weight. I've tried unsuccessfully for two years." It's a common experience, so you're definitely not alone if this resonates.
Bone health is something to watch closely. Anastrozole can weaken bones over time, so regular bone density monitoring is usually recommended. Calcium, vitamin D, or bone-strengthening medications may also be suggested by your care team. The good news is that many people do tolerate anastrozole well overall. Side effects don't necessarily reduce quality of life for everyone, and there are ways to manage most of them.
Always talk to your doctor or care team if side effects feel unmanageable — there are options, including switching medications if needed. That's not a failure, just part of finding what works best for you.
September 24
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