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I cannot take anastrozole without taking osteoporosis drugs which I refuse to take. With my tumor so small I don’t fit any guidelines. With double mastectomy I did the most drastic surgery right away. Tamoxifen almost killed me. Oncologist said I have a 3-5% chance of recurrence OFF MEDS. What would you do?

August 13
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A MyBCTeam Member

@A MyBCTeam Member

Only you can decide what to do.

I did not take any of the osteoporosis drugs.

You have 2 more Aromatase inhibitors to try.
Also. go on Pub Med and research trials with lower dose Exemestane and Letrozole as a back up idea…

August 13
MyBCTeam

That's a genuinely tough spot to be in, and it makes complete sense that you're questioning whether continuing treatment is worth it given everything you've been through.

Here's what the facts suggest about your situation: Your profile does carry some favorable factors:

- Very small tumor (4mm)
- No lymph node involvement Show Full Answer

That's a genuinely tough spot to be in, and it makes complete sense that you're questioning whether continuing treatment is worth it given everything you've been through.

Here's what the facts suggest about your situation: Your profile does carry some favorable factors:

- Very small tumor (4mm)
- No lymph node involvement
- Estrogen receptor-positive (hormone therapy works, but you've had serious reactions)
- Double mastectomy already completed
- A 3-5% recurrence risk off meds is genuinely low Anastrozole does carry real bone loss risks, especially post-menopause, since lowered estrogen accelerates bone thinning. That concern is completely valid and not something to dismiss. There are other aromatase inhibitors besides anastrozole — exemestane and letrozole — that may have slightly different side effect profiles. It may be worth asking your oncologist whether either of those is an option before stopping hormone therapy entirely. Ultimately, only you and your oncologist can weigh a 3-5% recurrence risk against the very real harm medications have caused you. Quality of life matters enormously in this decision — and that's not a small thing. A second oncology opinion could also help you feel more confident either way.

August 13

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