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Joint pain is one of the most common side effects of anastrozole, and it can persist or even worsen with long-term use. This happens because anastrozole significantly lowers estrogen levels, and estrogen plays a role in keeping joints comfortable and bones strong.
Common musculoskeletal side effects include:
- Joint Show Full Answer
Unfortunately I had moderate arthritis before cancer. When the doctors had me try Letrozole and the other 2 estrogen meds they made it so I could barely walk. I ended up not being able to tolerate them. However, the doctors did tell me that I could try every other day with the meds to see if it lessened the pain. If your pain is too bad you might check if you could try that schedule. Best of luck.
I’m on Letrozole (about 5 years now and 5 to go) and have had joint and muscle pain for most of the time I’ve been on it. I take 1000 mg of Hyaluronic Acid every day. I also drink about 1/3 cop of Tonic water every day for the quinine (I mix it with ice tea, Crystal Light or flavored water). It has helped. My joint pain is mainly in my knees and muscle pain in the legs. This has calmed it down, but took about a month before I noticed. Best of luck to you. You are in my prayers. 🫶
OMG... YES! My right knee and left wrist hurt for a really long time. It's inevitable. I take joint supplements with collagen and vitamin D3 with K2 and calcium. It's helped me. Plus I try to keep my joints moving as to not stiffen up on me. I hope you find your solution. I asked my oncologist about it, she was going to give me Letrozol but it also causes joint pain I opted to stay on Anastrozol since I been taking it for a year now. My system is already use to it. No nausea 😊
@A MyBCTeam Member
Let your Medical Oncology team know that you are having a lot of joint pain with Anestrozole.
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