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It's crazy that women who are stage 4 could be getting treated for a particular type of BC but there is no way of knowing if the type of cancer has changed and that's why the drug isn't working. It's been said the cancer itself finds a new fuel source but maybe the cancer just changes altogether
When a mets was found on my hip 2 years ago my doctor wanted a biopsy but I didn't want to go through another procedure.

The type of breast cancer, specifically its intrinsic subtype and receptor status… read more

May 20, 2025
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A MyBCTeam Member

It's interesting as is this the reason why some women's drug protocols stop working? Because if the cancer changed, the same drugs wouldn't work. My doctor wanted a bone mets biopsy 2 weeks after my surgery and I was in no mood to get into it. She said she wanted to find out if it was the same cancer. I find this stuff fascinating and enjoy researching.

May 20, 2025
A MyBCTeam Member

I got a bone mets biopsy. It ended up being similar to part of my breast tumors so I think it just confirmed there treatment choice more than anything else. I might ask my oncologist because now I am curious.

May 20, 2025
MyBCTeam

Research has shown that hormone receptor and HER2 status can indeed change when breast cancer metastasizes. This is why oncologists often recommend performing a biopsy on metastatic tumors - it helps determine if the cancer's characteristics have changed, which could affect treatment decisions. Different types of breast Show Full Answer

Research has shown that hormone receptor and HER2 status can indeed change when breast cancer metastasizes. This is why oncologists often recommend performing a biopsy on metastatic tumors - it helps determine if the cancer's characteristics have changed, which could affect treatment decisions. Different types of breast cancer tend to spread to different areas. For example, hormone receptor/HER2-positive cancers are more likely to spread to the liver, while hormone receptor-positive/HER2-negative cancers more commonly spread to the bones. Understanding these changes through biopsy results can help your medical team adjust your treatment plan for the best possible outcomes.

May 20, 2025
A MyBCTeam Member

Oh, I forgot to add that the mets have the same markers as the original cancer.

May 21, 2025
A MyBCTeam Member

Hi Barbara66, my recurred and mets cancer were identified as invasive ductal carcinoma, the same as the original cancer. Also the mets in right chest wall is from the IDC, not from the original right BC, which was DCIS. I didn't understand such a thing is even possible!

So I have breast cancer on my skin on the left and in my chest wall, right and left.

May 21, 2025

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