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Many women don't want to take these drugs which is understandable. Why do doctors want women on the drugs for 5-10 years? Do they think our bodies cells never stop dividing and continue to feed off and grow from estrogen
So being on these drugs for 5-10 yrs staves off cancer and offers another year of protection when treatment is done. Recurrence if it happens usually happens 5-10 yrs after diagnoses so are these drugs just buying time and our bodies cells never change permanently not to feed… read more

February 20, 2025 (edited)
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Answer Summary

Members engaged in a deeply informed discussion about why aromatase inhibitors and tamoxifen are prescribed for 5 to 10 years, with many... Read more

Members engaged in a deeply informed discussion about why aromatase inhibitors and tamoxifen are prescribed for 5 to 10 years, with many concluding that these drugs primarily buy time by blocking estrogen while being taken, but do not permanently change how cells respond to estrogen once treatment stops. Several members shared practical experiences with side effects ranging from manageable (letrozole causing minimal issues) to severe (Verzenio causing chemo-like symptoms), along with strategies like dosage reductions, exercise, vitamin D supplementation, and emerging tools like the Breast Cancer Index test to assess individual recurrence risk and determine whether extended treatment beyond five years is beneficial. A recurring theme was the tension between enduring difficult side effects for years versus facing potential recurrence, with members expressing frustration over the lack of significant treatment advances, the trade-off between quality of life and cancer prevention, and the reality that once hormone blockers are stopped, estrogen returns and protection diminishes, leaving many feeling they are navigating an imperfect system with limited long-term guarantees.

A MyBCTeam Member

And then there is exercise

Exercise releases a number of hormones and cytokines that can help prevent cancer, including catecholamines, myokines, and anti-inflammatory cytokines.

What are the benefits of exercise?
Being active can help you keep a healthy weight, which reduces the risk of 13 different types of cancer.

Exercising regularly can lower the risk of breast cancer and bowel cancer in particular. https://www.cancerresearchuk.org/about-cancer/c...

What are the benefits of exercise?
What are the benefits of exercise?
February 20, 2025
A MyBCTeam Member

@A MyBCTeam Member Your guess is as good as mine and its very hard to research. I often wonder why these drugs affect women after just one dose and other a few months later and sometimes not until a year later and is there any correlation how much estrogen they had in their bodies to begin with. Also the women who get hot flashes, vaginal dryness, mood changes, did they or did they not get the same during menopause. There has to be reasons. Personally, I had a simple menopause, my period just stopped and that was it. My cancer is estrogen dependent 80%. Who knows. I tried to find answers and spent a lot of time but found none

May 1, 2025
A MyBCTeam Member

Whether taking these hormone blockers or a ton of stuff that supposed to block estrogen, its not the hormone blocking drug or the supplements that is the problem, depleting estrogen any way is going to cause the same effects because its that depletion that cause the issues.

Without estrogen we are going to have side effects no matter what product causes the depletion of estrogen. Its not Anastrozole, Tamoxifen or the other AI's , anything that stops estrogen will give us the same result.

February 24, 2025 (edited)
A MyBCTeam Member

And who is going to take Hormone blockers forever like blood pressure or diabetic meds? I want to know more about these AI's, do they really only guard against recurrence while on them and if that is the case Oncologist need to tell that to their patients.

February 20, 2025
A MyBCTeam Member

Renee, I think many women think if they aren't having any side effects after the first few months they somehow got lucky but joint, bone and muscle pain can come on in a day. One day you are fine and the next its OMG why am I so stiff or what did I do to my knee and then it gets worse and there is OMG again, could this be from Anastrozole/Letrozole and when you realize yes, it is, it really throws you because you now wonder just how bad this will get.

May 2, 2025

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