Good Morning Barbara66, virginiavalley and Mary470 for always keeping me on my toes about types of breast cancers. Barbara66 I like how you always think outside the box and come up with some very good questions. Bravo to you ladies. Have a bless day.🙏🌹❤️

I don't know the answers any more than you do, Barbara66. It does seem odd in a way to have more than one type at a time. After all, if an ER+ tumor is feeding and growing off of estrogen in the system, what would the TN tumor be feasting on?

My guess would be that, all things being equal, they would go after the type of tumor that they thought they had the best chance at treating quickly. Since there are more treatment options for hormone receptor or HER2 variants, might they attack those first? But then again, since TN tends to be most aggressive, perhaps they would want to bring it down before it spread too far too fast? But, of course, that isn't always true, as some TN seem to be less aggressive than others. Perhaps it is one of those judgments that has to be made individually since no two are alike.

Together, and adjusting as needed for any conflicts. There are several ladies here who are unifocal but also Triple Positive.

There is a protein involved with tumor growth, that researchers are trying to find a way to disrupt, which would be especially helpful with TN.

Barbara, could you be thinking of HER2+? We have too many (over-expression) of a protein receptor. Triple Negative is called that because it does not have over-expression of either known hormone receptors (Estrogen or Progesterone) and does not have over-expression of the HER2 receptors.
TN= ER-. PR-, HER2-
Hugs!