It's a bisphosphonate in intravenous form. My baseline bone density scan came back as osteopenia, and that was before sudden menopause and the Ai. My oncology office offers it to all women on AIs who have osteopenia. I also consulted an endocrinologist who is an expert in bone density. I know some women, being treated elsewhere, whose bones are Ok but are taking it because it can reduce the risk of mets to the bones. The standard is once every 6 months for 2-3 years. I take vitamin D and calcium per doctor's advice. That's especially important if you are on Zometa. Note: women with mets also get Zometa to replenish the bones, but they get monthly infusions.

I just had my first infusion 2 days ago and the next day I felt really bad. I felt very achy, flu like symptoms and headache. I went to work but left after lunch. I took IBU. Then Naproxen which help the most. Today I feel much better and I hope tomorrow I will continue to improve.

@A MyBCTeam Member I will have my first zometa infusion this month. My most recent bone density showed starting of osteopenia in my hip. This information is so helpful. Thank you for sharing.

For AC I was told to expect flu-like symptoms. After I checked with my oncologist that it was safe, I took Claritin the day before and daily day of and three days after chemo. Seemed to work. No aches. Just the fatigue and light nausea.

I felt like a ballgame on a rainy day for 2 1/2 days after the 1st infusion and it took about a week to feel like myself again. I suggest Tylenol, rest and staying hydrated. You might want to cook a few meals - something light - ahead of time because you won't feel like doing very much. I drank chicken broth and moved around as much as I felt up to. Subsequent infusions are nothing like the 1st one. Blessings to you moving forward.