I've read things about Neratinib, (although lots of side effects) depending on your diagnosis? I'm on daily @Tamoxifen pills (and still getting @Herceptin infusions every 3 weeks) and have mild side effects from the pills, similar to what you are saying, but the doc and nurse said to give it a couple months. Hopefully our bodies will then adjust.

It’s my understanding that relative risk is very different from absolute risk.
For example a drug company can tell you that their drug reduces relative risk 50% and in reality your absolute risk lowers by a percentage point.
http://www.breastcancer.org/risk/understand/abs...

I’m pretty sure I’m starting it soon. (Recently had my last Herceptin infusion and I’m just waiting on confirmation from my insurer.) Have you started? If so, I’d love to hear how it’s going!

It was only recently approved and there are no long term studies yet. Based on the study that was done (one group got the drug and the other got placebo but in both groups the women were also having Herceptin/chemo/radiation/hormone) the difference between the two groups was about a little under 2% less recurrence risk. There are a few articles online you can review - as always it’s a matter of weighing the potential benefits against the side effects and risks.

I'm Her2 (triple positive too). I'm not done w/Herceptin yet, but I did ask my dock about Neratinib because I did research and learned about it. My onc wasn't convinced it was right for me, but I told him that I wanted to re-visit the option as I get closer to finishing Herceptin in the fall. So much can change between now & then with meds , treatments and FDA approvals, etc. When are you done w/Herceptin? Best of luck to you. Stay strong.