I took Tam for a year and a half. Side effects, such as hot flashes, diminished somewhat over this time period. Anxiety is trickier, as it's harder to winnow out the source. I'd expect time to deminish this, too, if it's Tam related. I'm sure the wrench that hormone therapy tosses into the mix, upsetting the balance, was a part of mine, but, ultimately, I had to have my thyroid meds adjusted-revving wayyyy too high. It's not at all uncommon for women treated for breast cancer to have their thyroid go wonky. And overstimulation of the thyroid can produce anxiety-like sensations- sweating, fear and the like. Worth getting your TSH checked to rule in or rule out.

((Hug))

I don't think it causes weight gain for everyone, I was also very dubious about starting it as I didn't want to be putting on weight with everything else. I have been lucky, no weight gain at all and I did need something for my depression. You are limited to which ones you can take with tamoxifen, try them and if they are no good then maybe something else will be. Good luck x

I've been on Tamxoifen since mid-March 2016. Yes I get hot flashes but not all the time and my periods did stop. I've been tired and moody but face it I've been through a lot since January of this year. Empty nest doesn't help either. I'm on it for 10 years also. Last night I told
my hubby only 9 1/2 years to go. But I look at it as a small price I have to pay to help keep the cancer away. I find I feel better when I go for my daily walks ( which I really try to do)

I have gained no weight while on it and on quite a high dose 150 mg.

I'm on Tamoxifen since May 2015 and I find my joints are very achy in the mornings worst and I find it hard to get mobilising but I've started taking a supplement of MorEPA which is an omega supple the to help joint health and will see if it helps. I also go regular to my beautician for full body massage to loosen out all the stress in the joints. That def helps me. Walking helps but knee can be quite painful at times. I remember people who has warned me about this side effect but it's the price to pay to decrease the chance of recurrence most women will gladly take .